What a phase 1 result can and cannot tell you

Started 5 January 2026 · 14 replies · 102 hearts · read 923 times

FabianBasel, CH · 5 January 2026

6 months ago

What a phase 1 result can and cannot tell you Writing it down partly to work out what I actually think.

Evidence question. I would rather have an honest "we do not know" than a confident answer.

What I would find most useful is not advice. It is somebody describing what their version of this was, and how long it went on for.

The thing that has surprised me most is how much of this is about other people rather than about me.

Sorry for the length. If anyone has been here, I would very much like to hear it.

PolaGdańsk, PL

Different experience here, for balance. Mine did not improve and in the end I stopped, and that was the right call for me. Both outcomes exist.

SunilFacilitatorBirmingham, UK

Noticing out loud that this conversation has drifted into comparison. That happens without anyone intending it and it does not help anyone. Let us come back to the person who asked.

IdrisCardiff, UK

Gently disagreeing with the reply above, or rather adding the other half of it.

Two things that helped me, neither of them clever: small amounts more often, and drinking a lot more than felt necessary.

NevGrimsby, UK

I would take that to a clinician rather than to us, and I would do it this week. Not because it is definitely serious — because it is the sort of thing that is much easier to rule out than to worry about.

BunnyWeston-super-Mare, UK

the reply above said something I want to sit with for a second.

Yes. All of this. I had the same in my third month and I remember thinking there was something specifically wrong with me, which there was not.

FlossieShrewsbury, UK

Mine lasted about seven weeks and then lifted over a few days. I cannot tell you why. I can tell you it lifted.

9me too 4

MorayElgin, UK

Similar here, and mine turned out to be a completely unrelated deficiency picked up on bloods.

WellsChester, UK

Building on what the reply above wrote rather than answering the original question.

I have been in this circle a year and this question comes round every few months. It is not a silly question. It is the question.

MableBolton, UK

Please do not read the comments under news articles about this. I lost a fortnight to that.

TobinCork, IE

#10

Reading the reply above, I recognised more of that than I expected to.

I asked my nurse the same question and she said something I have repeated ever since: that the aim is to keep you on treatment, not to get you up the schedule.

TacitaRome, IT

#11

The phrase that unlocked my appointment was asking what specifically she wanted me to watch for. It moved us from reassurance to a plan in about thirty seconds.

TamarPlymouth, UK

#12

No advice, just recognition. That sounds exhausting and I am sorry you are in it.

SunilFacilitatorBirmingham, UK

#13

Two things, both boring. First, none of us can tell you what to take. Second, the conversation you want to have is with your prescriber, and we can help you write it down.

FabianBasel, CH

#14

the reply above — yes, and the bit that took me longest to accept was the next part.

I keep a two-line diary and it is the only reason I could answer this question about myself. Worth starting even now.

5me too 2