Orforglipron and the oral pipeline

Started 11 November 2024 · 23 replies · 296 hearts · read 4.2k times

TacitaRome, IT · 11 November 2024

1.7 years ago

A question rather than an update: Orforglipron and the oral pipeline

Evidence question. I would rather have an honest "we do not know" than a confident answer.

The thing that has surprised me most is how much of this is about other people rather than about me.

My prescriber has been fine, genuinely. The problem is that I get nine minutes twice a year and there is no version of nine minutes that covers this.

What I keep tripping on is not the physical bit. It is the not knowing whether what I am experiencing is normal, and having nobody to ask who is not either selling something or frightened for me.

Sorry for the length. If anyone has been here, I would very much like to hear it.

NevGrimsby, UK

Practical, boring answer: write the three questions down before you go in. I have never once remembered them otherwise.

IdrisCardiff, UK

the opening post said something I want to sit with for a second.

I did exactly the same and felt terrible about it. You have not done anything wrong.

11me too 1

SunilFacilitatorBirmingham, UK

Building on what the opening post wrote rather than answering the original question.

Before anyone offers a remedy: what has been described here is on the list of things that need a clinician today rather than a thread. I am going to be firm about that, kindly.

AbramAmsterdam, NL

Coming back to this a fortnight later to say it settled. Leaving the update because I hate reading threads that stop.

IvorLlanelli, UK

For what it is worth, the trial data on this is thinner than the confidence of the internet would suggest. Worth knowing when you read the posts.

FabianBasel, CH

It got worse before it got better for me, which I wish someone had said. About ten days of worse.

PolaGdańsk, PL

The thing that changed it for me was going slower, agreed with my prescriber. I am not suggesting you do that. I am saying the conversation exists.

9me too 6

BunnyWeston-super-Mare, UK

Gently disagreeing with the reply above, or rather adding the other half of it.

Have you got anyone who can be with you when you do it? It made an enormous difference to me and I felt silly asking.

MableBolton, UK

I have been in this circle a year and this question comes round every few months. It is not a silly question. It is the question.

MorayElgin, UK

#10

Similar here, and mine turned out to be a completely unrelated deficiency picked up on bloods.

FlossieShrewsbury, UK

#11

Yes. All of this. I had the same in my third month and I remember thinking there was something specifically wrong with me, which there was not.

TobinCork, IE

#12

Mine lasted about seven weeks and then lifted over a few days. I cannot tell you why. I can tell you it lifted.

TamarPlymouth, UK

#13

Two things that helped me, neither of them clever: small amounts more often, and drinking a lot more than felt necessary.

TacitaRome, IT

#14

Reading the reply above, I recognised more of that than I expected to.

I would take that to a clinician rather than to us, and I would do it this week. Not because it is definitely serious — because it is the sort of thing that is much easier to rule out than to worry about.

8me too 3

NevGrimsby, UK

#15

Please do not read the comments under news articles about this. I lost a fortnight to that.

IdrisCardiff, UK

#16

What the reply above described happened to me too, in a slightly different order.

I asked my nurse the same question and she said something I have repeated ever since: that the aim is to keep you on treatment, not to get you up the schedule.

WellsChester, UK

#17

the reply above — yes, and the bit that took me longest to accept was the next part.

Different experience here, for balance. Mine did not improve and in the end I stopped, and that was the right call for me. Both outcomes exist.

14me too 9

AbramAmsterdam, NL

#18

The phrase that unlocked my appointment was asking what specifically she wanted me to watch for. It moved us from reassurance to a plan in about thirty seconds.

IvorLlanelli, UK

#19

I am the person who had the frightening version of this. I went in, it was investigated, and it was not what anyone feared. Going in is the whole of my advice.

11me too 1

FabianBasel, CH

#20

Reading the reply above, I recognised more of that than I expected to.

My experience was very boring, which I offer as data. Some of us just get a dull time of it.

PolaGdańsk, PL

#21

No advice, just recognition. That sounds exhausting and I am sorry you are in it.

SunilFacilitatorBirmingham, UK

#22

Gently disagreeing with the reply above, or rather adding the other half of it.

I want to slow this down a little. There are four different answers flying about and they are all somebody's real experience, which makes them true and not necessarily relevant to the person who asked.

24me too 1

MableBolton, UK

#23

I keep a two-line diary and it is the only reason I could answer this question about myself. Worth starting even now.