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Guides

Clinical

Results, trials and appointments — what the evidence says and where it runs out.

clinicalhow-to

Reading your bloodwork without panic

How to open a set of results without your stomach dropping — what a reference range actually means, which numbers move for dull reasons, and when to ring somebody today.

10 min · reviewed by Mira · updated 8 May 2026

clinical

A1c, and what it is not

What glycated haemoglobin actually measures, the units confusion nobody warns you about, the things that make it lie, and why it is a poor scoreboard for a fortnight.

8 min · reviewed by Mira · updated 16 Apr 2026

clinical

Cardiovascular outcomes: what SELECT showed

The trial that changed how clinicians talk about these drugs — who was in it, what it actually found, how big the effect was in plain terms, and the claims stacked on top of it.

10 min · reviewed by Sunil · updated 2 Jun 2026

clinical

Kidney numbers, and what FLOW showed

eGFR, creatinine and albumin explained without jargon, what the FLOW trial found in people with type 2 diabetes and kidney disease, and the everyday kidney risk that matters more.

9 min · reviewed by Mira · updated 21 May 2026

clinical

Thyroid and GLP-1: what is known

The rodent finding behind the warning label, what human data has and has not shown since, what it means if you already take levothyroxine, and where the honest uncertainty sits.

9 min · reviewed by Mira · updated 29 Apr 2026

clinical

Type 2 and GLP-1: a plain summary

What these medicines do for type 2 diabetes, what the outcome trials found, the hypoglycaemia and retinopathy questions, and the practical things that change in ordinary care.

10 min · reviewed by Mira · updated 18 Jun 2026

clinicalhow-to

Reading a trial without a PhD

The method our reading group uses on every paper — five questions, in order, that let anyone tell what a study actually showed from what people are claiming it showed.

11 min · reviewed by Sunil · updated 3 Jul 2026

clinicalhow-to

Talking to your GP when time is short

How to get something useful out of ten minutes — the one-page prep, the opening sentence that changes the appointment, and what to ask for in writing before you leave.

8 min · reviewed by Mira · updated 14 May 2026

clinical

Plateaus: what is happening, and what helps

Why change slows or stops, what the trial curves actually look like, what is worth checking, and why a plateau is a physiological event rather than a verdict on you.

10 min · reviewed by Ada · updated 25 Jun 2026

clinical

Coming off: what to expect

Stopping is an ordinary shape, not a failure — what the withdrawal trials found, what the weeks afterwards tend to feel like, and what is worth arranging first.

10 min · reviewed by Benedikt · updated 9 Jul 2026